Effects of the Anti-Androgen Finasteride on 5-Alpha-Reductase Activity in Human Gingival Fibroblasts in Response to Minocycline

The study found that finasteride can inhibit 5-alpha-reductase activity in human gingival fibroblasts, which could be beneficial for treating hair loss and alopecia. The study involved 12 subjects aged 30-50 years. The optimal inhibitory concentration was determined through experiments with multiple cell-lines. The study suggests that finasteride may be useful in treating androgen-related conditions in the gingiva, but further research is needed to confirm these findings and determine the optimal dosage and treatment duration.