Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome

    May 2019 in “ Frontiers in Endocrinology ”
    Mehri Jamilian, Fatemeh Foroozanfard, Naghmeh Mirhosseini, Elham Kavossian, Esmat Aghadavod, Fereshteh Bahmani, Vahidreza Ostadmohammadi, Mersedeh Kia, Tahereh Eftekhar, Elnaz Ayati, Mostafa Mahdavinia, Zatollah Asemi
    This study evaluated the effects of melatonin supplementation in 56 women with polycystic ovary syndrome (PCOS) over 12 weeks. Participants were divided into two groups, with one receiving 5 mg of melatonin and the other a placebo. Results showed that melatonin significantly reduced hirsutism, serum total testosterone, high-sensitivity C-reactive protein (hs-CRP), and plasma malondialdehyde (MDA) levels. It also increased plasma total antioxidant capacity (TAC) and total glutathione (GSH) levels. Additionally, melatonin downregulated the gene expression of interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α). Overall, melatonin administration improved hormonal, inflammatory, and oxidative stress parameters in women with PCOS.
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