Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

This review from 2021 examined the potential of curcumin and its formulations in treating peripheral neuropathic and postoperative pain, highlighting its antioxidant and anti-inflammatory properties. Despite challenges with low bioavailability, curcumin showed promise in preclinical and clinical studies by reducing pain behaviors, inflammation, and oxidative stress. It was particularly effective in models of diabetic neuropathy and chronic constriction injury, with improved formulations like nano curcumin and Theracurmin enhancing its efficacy. Clinical studies, including those with up to 160 participants, demonstrated curcumin's ability to reduce pain and improve outcomes in conditions like diabetic sensorimotor polyneuropathy and chemotherapy-induced side effects. However, the review emphasized the need for more research to optimize curcumin's clinical application and confirm its therapeutic potential.