Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis

The systematic review and meta-analysis evaluated the effectiveness and safety of oral Janus kinase inhibitors in children aged ≤12 with alopecia areata. The study included various analyses such as pooled outcomes for SALT change, complete scalp hair regrowth, and adverse events. Subgroup analyses were conducted based on medicine type, alopecia subtype, age group, and continent. The findings support the use of Janus kinase inhibitors in this demographic, highlighting significant hair regrowth and manageable adverse events, although the study emphasizes the need for further research to confirm long-term safety and efficacy.