Editorial Comment

The document discussed the challenges in accurately diagnosing prostate cancer, particularly high-grade disease, using conventional transrectal ultrasound-guided biopsy. It highlighted that this method often missed cancer or inaccurately estimated its extent and grade, with false negatives increasing as prostate size increased. The document suggested that taking more biopsy cores or using template-based biopsies could improve diagnostic accuracy. Additionally, it referenced studies on the influence of prostate volume and the potential benefits of using magnetic resonance imaging before biopsy to enhance cancer detection.