Dual effects of human adipose tissue-derived mesenchymal stem cells in human lung adenocarcinoma A549 xenografts and colorectal adenocarcinoma HT-29 xenografts in mice

The study investigated the effects of human adipose tissue-derived mesenchymal stem cells (hATMSCs) on tumor growth in mice with lung adenocarcinoma A549 and colorectal adenocarcinoma HT-29 xenografts. It was found that hATMSCs inhibited the growth of A549 tumors but promoted the growth of HT-29 tumors. Gene expression analysis revealed that hATMSCs altered numerous genes in A549 tumors, while no significant changes were observed in HT-29 tumors. The study highlighted the role of histone cluster 1, H2aj, neuropeptide Y receptor Y4, and differential phosphorylation of NF-κB p65 in these effects. These findings provided molecular insights into the dual effects of hATMSCs on different cancer types, though further research was needed to confirm these results across various cancers.