Dual Effects of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Human Lung Adenocarcinoma A549 Xenografts and Colorectal Adenocarcinoma HT-29 Xenografts in Mice

The study investigated the effects of human adipose tissue-derived mesenchymal stem cells (hATMSCs) on tumor growth in mice with human lung adenocarcinoma A549 and colorectal adenocarcinoma HT-29 xenografts. It found that hATMSCs inhibited the growth of A549 tumors but promoted the growth of HT-29 tumors, with these dual effects observed in both in vivo and in vitro experiments. Gene expression analysis showed significant changes in A549 tumors treated with hATMSCs, particularly in NF-κB signaling, while HT-29 tumors showed fewer changes. The study highlighted the complexity of hATMSCs' role in cancer, suggesting their effects might depend on the cancer type, and called for further research to confirm these findings across various cancer types.