Development and progression of alopecia in the vitamin D receptor null mouse
January 2006
in “Journal of cellular physiology”
TLDR Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.
In this study, researchers found that mice lacking the vitamin D receptor (VDR) gene developed alopecia due to disrupted hair follicle cycling. The hair follicles of Vdr null mice deteriorated during the first catagen phase, failing to cycle normally. This disruption was linked to increased expression of the hairless (Hr) gene, a regulator of hair follicle cycling. Hr levels were higher in Vdr null mice compared to wildtype controls, suggesting that VDR is necessary for regulating Hr expression and normal hair follicle cycling. Both VDR and Hr were essential for maintaining hair follicle structure and function.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
Hairless protein can block vitamin D activation in skin cells.
research 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis
The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.
research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues the Alopecia in Vitamin D Receptor Null Mice
Vitamin D receptor is crucial for starting hair growth after birth.
research Molecular Mechanisms Regulating Hair Follicle Development
Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
research Atrichia Caused by Mutations in the Vitamin D Receptor Gene is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene
research Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions
ODC transgenic mice can model human hair loss with skin lesions.
Related
research 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath
A specific mutation in the TRPV3 gene causes hair follicle cells to develop improperly, leading to hair loss.
research Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle
Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
research Effects of EGF on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles
EGF makes hair follicles grow longer but stops hair production.