Clinical Snippets: Dermatology Studies on Sunburn, Hair Loss, and More

    March 2003 in “ Journal of Investigative Dermatology ”
    Lowell A. Goldsmith
    TLDR Early sunburn treatment with certain inhibitors may reduce skin cancer risk.
    The document discussed several studies related to dermatology. One study suggested that early treatment of sunburn with cyclo-oxygenase inhibitors could reduce skin cancer risk by increasing apoptosis and eliminating mutated cells. Another study found that COX-2 expression in hair follicles led to premature catagen and alopecia in mice, which was preventable with COX-2 inhibitors, indicating potential hair-related effects in humans. Additionally, research on Hailey-Hailey keratinocytes linked low ATP levels to cytoskeletal disorganization. A study on neuropathy and ulcers showed that 17-beta-estradiol increased Nerve Growth Factor secretion, suggesting hormonal treatments for skin ulcers. Housekeeping genes were highlighted for their unexpected role in cutaneous and uterine leimyomas due to fumarate hydratase deficiency. Lastly, AS2O3 was noted for inducing apoptosis in T cells, with potential applications in treating CTCL/Sezary's syndrome.
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