Curly: A New Hair Defect Mutation in the SELH/Bc Mouse Strain

The study focused on the curly mutation (cur), an autosomal recessive mutation in the SELH/Bc mouse strain, characterized by a waved and ruffled coat, crimped and broken vibrissae, and potential hair loss at various body parts in later life. The mutation was mapped to the distal end of chromosome 11, within a 4-6 cM region containing several dominant hair defect mutations and keratin genes. The research involved 32 homozygous curly F2 mice from a cross with the LM/Bc strain and 71 F2 mice from a cross with the AXB-10/Pgn strain, aiming to refine the mutation's location and its relation to keratin genes. This mutation was significant for understanding genetic disorders and mutation mechanisms in the SELH strain.