Curly: A New Hair Defect Mutation in the SELH/Bc Mouse Strain
January 2009
Studysummary This study mapped the curly mutation in mice to a specific region on chromosome 11, identifying it as a candidate model for studying human genetic hair disorders.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study focused on the curly mutation (cur), an autosomal recessive mutation in the SELH/Bc mouse strain, characterized by a waved and ruffled coat, crimped and broken vibrissae, and potential hair loss at various body parts in later life. The mutation was mapped to the distal end of chromosome 11, within a 4-6 cM region containing several dominant hair defect mutations and keratin genes. The research involved 32 homozygous curly F2 mice from a cross with the LM/Bc strain and 71 F2 mice from a cross with the AXB-10/Pgn strain, aiming to refine the mutation's location and its relation to keratin genes. This mutation was significant for understanding genetic disorders and mutation mechanisms in the SELH strain.
