Skin Lesions Observed in COVID-19 Infection

    Mariko Niki, Yoshiaki Kubo
    TLDR COVID-19 can cause various skin symptoms, with different patterns seen in younger and older patients.
    COVID-19, caused by SARS-CoV-2, primarily affects the respiratory system but also presents various skin symptoms classified under the acronym "GROUCH." These include generalized maculopapular eruptions, Grover’s disease, livedo reticularis, urticarial, and chilblain-like lesions. Chilblain-like lesions are more common in younger patients with fewer systemic symptoms, while purpuric and livedoid lesions are more frequent in older, severely affected patients. Long-term symptoms post-COVID-19 affect 80% of patients, with hair loss occurring in 25%, often due to telogen effluvium, which typically resolves within 6 months. Skin reactions, such as "COVID-arm," have also been noted post-vaccination, predominantly in women, possibly due to a cross-reaction with polyethylene glycol. The exact mechanisms behind these cutaneous manifestations remain unclear, highlighting the importance of considering COVID-19 history and vaccination status during consultations.
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