COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection?

    December 2022 in “ Sudan Journal of Medical Sciences ”
    Chow Suet-May, Kuok Sin-Yee, Lee Jia-Qing, Goh Pey-Wen, Harleen Kaur A P Ranjit Singh, Timothy Tan Zhi-Zheng, Jhi Biau Foo, Sharina Hamzah, Renukha Sellappans, Hui-Yin Yow
    TLDR Vaccination is the most effective way to reduce COVID-19 transmission.
    This review paper evaluates the effectiveness of repurposed drugs and novel therapies for treating COVID-19. Remdesivir is the only FDA-approved drug for COVID-19 treatment, while several others, such as casirivimab and imdevimab, baricitinib (with remdesivir), bamlanivimab, tocilizumab, and IL-6 inhibitors, have Emergency Use Authorization. Additionally, cepharanthine, sotrovimab, and XAV-19 show potential in managing COVID-19 based on in vitro and clinical studies. Despite these efforts, the rapid mutation of SARS-CoV-2 and limited understanding of COVID-19 continue to pose challenges, with vaccination being the most effective method to reduce transmission. Ongoing research aims to develop more effective treatments.
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