A Case of the Cons: How Contraception Confused Congenital Adrenal Hyperplasia for Conn

    October 2020 in “ Journal of the American Society of Nephrology ”
    Linda-Marie U. Lavenburg, Sanjeev R. Shah, Sandeep Aggarwal
    TLDR Drospirenone can hide symptoms of certain hormonal disorders, complicating diagnosis.
    This case study described a 21-year-old female initially misdiagnosed with polycystic ovarian syndrome (PCOS) and treated with drospirenone-ethinyl estradiol, which masked symptoms of congenital adrenal hyperplasia (CAH) due to 11-beta hydroxylase deficiency (11BHD). The patient presented with hypokalemic alkalosis, hypertension, and hirsutism. After discontinuing the oral contraceptive, further investigation revealed elevated ACTH, DHEA-S, 11-deoxycortisone, and testosterone levels, leading to a diagnosis of non-classical CAH. Treatment with hydrocortisone normalized her blood pressure and electrolyte levels. The study highlighted the potential for drospirenone to obscure underlying endocrinopathies and suggested the need for clinical trials to evaluate its role in treating such conditions.
    Discuss this study in the Community →

    Related Community Posts Join

    4 / 4 results

    Similar Research

    5 / 393 results
      Polycystic Ovary Syndrome in Adolescents

      research Polycystic Ovary Syndrome in Adolescents

      May 2010 in “Current Women's Health Reviews”
      The document concludes that early diagnosis and treatment of PCOS in teenagers is important for managing symptoms and preventing long-term health problems.
      Female Hyperandrogenism

      research Female Hyperandrogenism

      9 citations , November 2013 in “Presse Medicale”
      The document concludes that managing female hyperandrogenism requires a combination of identifying the cause, lifestyle changes, medication, and cosmetic treatments.
      Is Hormonal Treatment Still an Option in Acne Today?

      research Is Hormonal Treatment Still an Option in Acne Today?

      31 citations , June 2015 in “British Journal of Dermatology”
      Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.
      Hormonal Therapies for Acne

      research Hormonal Therapies for Acne

      26 citations , October 2016 in “Clinics in Dermatology”
      Hormonal treatments can improve acne, but they come with potential side effects and risks.