Collodion Baby Case Series: The Success of Oral Retinoic Acid

    May 2018 in “ Türk pediatri arşivi : İstanbul çocuk kliniği dergisi ”
    Banu Mutlu Özyurt, Özge Sürmeli Onay, Özlem Ersoy
    TLDR Oral retinoic acid effectively treated collodion baby, with hair loss as the main side effect.
    The study presented a case series involving five newborns with collodion baby syndrome, treated with oral retinoic acid (0.5–1 mg/kg/day). The treatment led to significant clinical improvements in skin and eye conditions by the 7th-10th day, with mild hair loss as the only adverse effect. Patients were discharged between the 11th and 42nd days, continuing on a reduced dosage. The findings suggested that oral retinoic acid could be a promising therapeutic option for managing severe ichthyosis, though further experience and monitoring for long-term effects were necessary.
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