Collodion Baby Case Series: The Success of Oral Retinoic Acid

May 2018 in “ Türk pediatri arşivi : İstanbul çocuk kliniği dergisi ”

Banu Mutlu Özyurt, Özge Sürmeli Onay, Özlem Ersoy

oral retinoic acid collodion baby syndrome ichthyosis hair loss retinoic acid

TLDR Oral retinoic acid effectively treated collodion baby, with hair loss as the main side effect.

The study presented a case series involving five newborns with collodion baby syndrome, treated with oral retinoic acid (0.5–1 mg/kg/day). The treatment led to significant clinical improvements in skin and eye conditions by the 7th-10th day, with mild hair loss as the only adverse effect. Patients were discharged between the 11th and 42nd days, continuing on a reduced dosage. The findings suggested that oral retinoic acid could be a promising therapeutic option for managing severe ichthyosis, though further experience and monitoring for long-term effects were necessary.

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