Clinicopathological, Trichoscopic, and Biochemical Parameters in Females with Patterned Hair Loss

The study "Clinicopathological, trichoscopic and biochemical parameters in females with patterned hair loss" examined 37 females aged 18-45 years who were experiencing a reduction in hair volume and diffuse thinning over the crown. The majority of these females had Ludwig grade 1 hair loss. The study found that serum levels of testosterone were significantly related to clinical signs of hyperandrogenism. Trichoscopy revealed that hair diameter variability and peri pilar sign were the most common findings (62.2% each). Histopathological examination showed that the most common finding was perifollicular infiltrate (70.3%). The study concluded that female pattern hair loss (FPHL) can contribute to severe psychological distress and, despite its high prevalence, its diagnosis and treatment still pose several difficulties in clinical practice. The pathogenesis of FPHL, although believed to be influenced by hormonal factors, remains unclear.