Proposal for Clinical Classification of Cutaneous Manifestations in COVID-19 and Post-Vaccination Against SARS-CoV-2: An Observational Study

The observational study conducted in Mato Grosso, Brazil, from July 2020 to July 2022, involved 108 patients with skin manifestations related to COVID-19 or vaccination against SARS-CoV-2. The study found that 79.6% of patients had skin manifestations due to COVID-19, 13.9% had skin reactions exclusively after vaccination, and 6.5% had skin manifestations related to both. A total of 143 different dermatological manifestations were diagnosed and classified into five categories: peri-infectious and post-infectious immune-inflammatory reactions related to COVID-19 (62.2%), exacerbation of pre-existing skin diseases by COVID-19 (4.2%), skin manifestations resulting from the socio-sanitary context of the pandemic (2.1%), adverse drug reactions from the treatment of COVID-19 (14%), and adverse skin reactions from SARS-CoV-2 vaccines (17.5%). This classification could help physicians manage dermatological lesions associated with COVID-19 or post-vaccination.