Efficacy and Safety of Standardized Cinnamon Bark Extract for the Prevention of Chemotherapy-Induced Weight Loss and Alopecia in Patients with Breast Cancer: A Randomized, Double-Blind, and Placebo-Controlled Study

August 2019 in “ Asian journal of pharmaceutical and clinical research ”

Ajay Mehta, Suchitra Ajay Mehta, Prasad Thakurdesai

alopecia chemotherapy-induced alopecia Cinnamon bark extract IND02 breast cancer chemotherapy hair loss chemotherapy-induced hair loss Cinnamon extract

TLDR Cinnamon bark extract may help prevent weight loss and hair loss in breast cancer patients during chemotherapy and is safe to use.

In a study conducted on 34 female breast cancer patients, the supplementation with IND02, a standardized Cinnamon bark extract, was evaluated for its effectiveness in preventing chemotherapy-induced side effects such as weight loss and alopecia. The randomized, double-blind, placebo-controlled trial administered IND02 capsules (400 mg, thrice daily) or a placebo during the first four 21-day cycles of standard chemotherapy. The results indicated that patients treated with IND02 experienced significant protection against severe weight loss and hair loss compared to the placebo group. Additionally, IND02 was found to be safe and well-tolerated. The study concluded that IND02 shows promise as a concomitant treatment for preventing weight loss and alopecia in breast cancer patients undergoing chemotherapy.

View this study on innovareacademics.in →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Is it possible to create an estrogen mesotherapy/topical that doesn't go systemic?

in Research/Science 6 upvotes 1 month ago

The conversation discusses the potential of using topical estrogen treatments for hair loss without systemic absorption, highlighting challenges and possible solutions like using estriol. It also mentions other treatments like topical finasteride, microneedling, and scalp massage, while noting the limitations and side effects of current options.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 2 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community 6 week update fellas, 5mg oral minoxidil. Pics are 2nd June – 10th July

in Progress Pictures 2 years ago

, you can find it online with a script This user was discussing their progress with hair loss treatments including 5mg oral Minoxidil and combining 3mg oral Minoxidil with MTF HRT. They also discussed side effects of increased body hair in other parts of the body.

community DUPA VS. FAPD, which is more treatable? Which is worse?

in Research/Science 8 upvotes 2 weeks ago

DUPA is considered more treatable than FAPD, as FAPD involves scarring that prevents hair regrowth. The user has started treatment with oral dutasteride and minoxidil, hoping for better results than previous treatments.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 2 months ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 month ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

Related Research

2 / 2 results

research Olanzapine Induced Hair Loss: A Case Report

9 citations, October 2012 in “Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology”

Stopping the drug olanzapine can reverse hair loss caused by it.

research Hair Loss With Rapid Weight Loss

5 citations, February 1977 in “Archives of Dermatology”

Eating more protein during fast weight loss can prevent hair loss.