Influence of Chronic Restraint Stress on Anagen Stage in Skin of Mice

January 2012 in “ Zhongguo linchuang xinlixue zazhi ”

Zhang Xing-guo

anagen stage hair cycle oxidative stress chronic restraint stress cortisol TBARS SOD GSH-Px antioxidants hair growth phase stress hormone thiobarbituric acid reactive substances superoxide dismutase glutathione peroxidase

TLDR Chronic stress delays hair growth in mice, but antioxidants can help reverse this.

The study investigated the effects of oxidative stress from chronic restraint stress on the hair cycle in mice. It found that chronic restraint stress significantly decreased mouse movement, increased plasma cortisol and skin TBARS levels, and decreased SOD and GSH-Px activity, leading to a delay in the anagen stage of the hair cycle. However, when antioxidants were added, the TBARS levels and GSH-Px activity showed no significant difference compared to the control group, and the delay in the anagen stage was partially reversed. This indicated that oxidative stress from chronic restraint stress delayed the anagen phase in the hair cycle of mice.

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