Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

The study investigates an allantoin-enriched pectin hydrogel for treating skin wounds, demonstrating its hydrophilic properties and healing efficacy through functional groups like carboxylic acid and amine. In a rat model, the hydrogel showed significant improvement in wound healing, reducing healing time by 71.43% and achieving complete wound closure in 15 days. The hydrogel's structure, with allantoin distributed throughout and a heterogeneous pore distribution, enhances interaction with cells, promoting effective wound drying and healing.