Cell Kinetics of Anagen Scalp Hairs Under Physiological and Pathological Conditions

The study investigated the cell kinetics of anagen scalp hair bulbs in various conditions using DNA flow cytometry. In healthy males (n = 50), the highest proliferative activity was found in the lower bulbar segment, decreasing towards the isthmus. In male pattern baldness (n = 15) and hirsutism (n = 13), an increase in S phase cells was observed compared to healthy controls, with hirsutism showing a correlation with dehydroepiandrosterone sulfate levels. Thyroid conditions also affected S phase values, with hyperthyroidism increasing and hypothyroidism decreasing these values. The study concluded that DNA flow cytometry was effective for evaluating the impact of physiological and hormonal factors on hair bulb cell cycle kinetics.