Celiac Disease Associated with Alopecia Areata: A Multicenter Case-Control Study
November 2024
in “
Journal of the American Academy of Dermatology
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → Studysummary People with celiac disease have a higher risk of developing alopecia areata.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This multicenter case-control study investigated the association between celiac disease (CD) and alopecia areata (AA) using a large US database of approximately 64 million patients. The study identified 509,910 patients with CD and compared them to a control group of 622,747 patients. Results showed that patients with CD have an elevated risk of developing AA, with an odds ratio of 1.25 and a significant P-value of <.0001. The study suggests that shared genetic polymorphisms and elevated chemokines may explain this association. Despite limitations such as potential errors in data and focusing only on the US population, the large sample size supports the association between CD and AA. Further research is recommended to better understand the link between gut autoimmunity and hair follicle health.
