Castleman's Disease Combined with the Development of Systemic Lupus Erythematosus

A 16-year-old boy presented with hair loss and facial erythema, and was diagnosed with Castleman’s disease (CD) after various tests and imaging revealed lymph node enlargement and reactive proliferation. Despite normal C-reactive protein levels and negative tests for several antibodies, the antinuclear antibodies test was positive. The patient was treated with five cycles of fludarabine and cholera toxin, resulting in a significant reduction in lymph node size and no recurrence during follow-up.