Carcinogenic Nitrite Preparations

The document from 1978 discusses two types of hair loss associated with oral contraceptive (O.C.) use. The first type, a diffuse effluvium, typically begins 3-5 months after starting O.C. use and resolves spontaneously within a few weeks; this condition is considered completely harmless and is most often linked to combination O.C. preparations. The second type, androgenetic alopecia, is more serious and usually occurs after 6 months of O.C. use; it is specifically caused by O.C.s containing a gestagen component that is a nortestosterone derivative. Treatment for androgenetic alopecia involves switching to a nortestosterone-free O.C. or stopping O.C. use altogether. For spontaneous cases of androgenetic alopecia, gestagens with anti-androgenic effects, such as cyproterone acetate or chlormadinone acetate, are used, but the concentrations in O.C.s are insufficient for treatment, necessitating the use of specialized preparations like Androcure.