Biphasic Regulation of HMG-CoA Reductase Expression and Activity During Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses

    April 2008 in “ Journal of Biological Chemistry ”
    Dana Schiefelbein, Itamar Goren, Beate Fißlthaler … Stefan L. Frank
    Studysummary This study found that simvastatin interfered with insulin-induced VEGF expression and keratinocyte proliferation during skin repair in mice, effects that could be reversed by mevalonate.
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