Promoting Biomechanical Properties of Incisional Wound Repair by Mesenchymal Stem Cell Transplantation
April 2025
in “
WORLD JOURNAL OF PLASTIC SURGERY
”
Studysummary This study reported that stem cells derived from semi-solid bone marrow improved the healing of diabetic incision wounds in rats by increasing epidermal thickness and blood vessel growth, and reducing hair follicle destruction, cellular penetration, diffuse fibrosis, and necrosis compared to control groups.
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This study investigated the therapeutic potential of semi-solid bone marrow-derived mesenchymal stem cells (BMMSCs) in improving wound healing in diabetic conditions using 45 Albino Wistar rats. The rats were divided into three groups, with diabetes induced in all groups. The group treated with BMMSCs showed improved wound healing, evidenced by increased epidermal thickness and blood vessel growth, without hair follicle destruction, cellular penetration, diffuse fibrosis, or necrosis, compared to the saline and control groups. Additionally, the BMMSCs group demonstrated higher energy absorption and improved biomechanical properties of the wound area. The study concludes that stem cells can enhance the healing of diabetic incision wounds.
