Becker's Nevus with Ipsilateral Breast Hypoplasia: Improvement with Spironolactone

    February 2003 in “Journal of Dermatology
    Jae Hoon Jung, You Chan Kim, Hyang Joon Park, Yong Woo Cinn
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    TLDR Spironolactone may help enlarge a small breast linked to Becker's nevus.
    In the 2003 study, a 17-year-old female with Becker's nevus and ipsilateral breast hypoplasia was treated with spironolactone, an anti-androgenic agent. After one month of treatment with 50 mg daily, there was a noticeable enlargement of the hypoplastic breast, while no pigmentary changes occurred in the nevus. This case supports the hypothesis that breast hypoplasia associated with Becker's nevus may be related to increased androgenic receptor activity in the affected area, and that spironolactone may counteract this effect by downregulating the androgen receptors. The study suggests that spironolactone could be a potential treatment for breast hypoplasia in the context of Becker's nevus. However, the study is limited to a single case, and further research would be needed to confirm these findings.
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