Baseline Methotrexate Does Not Impact the Incidence of Infliximab Infusion Reactions: Results from a Canadian Real-World Treatment Registry

The document reports on a case of ashy dermatosis, a rare skin condition characterized by ash-gray patches, treated successfully with clofazimine. A 46-year-old man with a history of gray-bluish-colored macules with an erythematous border on his trunk and upper thighs was diagnosed with ashy dermatosis through histologic examination. Treatment with clofazimine 100 mg daily for 3 months, followed by 100 mg every other day for another 3 months, led to significant improvement and clearing of the macules, with no new lesions appearing. After 6 months of follow-up, the patient remained lesion-free. This case supports the therapeutic efficacy of clofazimine for ashy dermatosis, which may work due to its anti-inflammatory and immunomodulatory actions. Other treatments for ashy dermatosis have shown variable results, and clofazimine's cosmetic effect of producing uniform skin coloring may also contribute to its effectiveness. No commercial support was identified for this study.