Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia
June 2000
in “The American journal of pathology”
TLDR The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.
A spontaneous autosomal recessive mutation in DBA/1LacJ mice, named asebia-2J, exhibited mild scaly skin, progressive scarring alopecia, slightly runted growth, and photophobia. Crosses with asebia-J mutants confirmed allelism. Histological analysis showed both mutants had extreme sebaceous gland hypoplasia, abnormally long anagen follicles, retained inner root sheath, hair fiber perforation, and progressive follicular scarring. The study proposed that the absence of functional sebaceous glands leads to hair follicle destruction, highlighting the gland's importance in follicular biology and providing a model for human scarring alopecias.
View this study on ajp.amjpathol.org →
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