Expression and Localization of Artemis Serine 516 Phosphorylation in Human Scalp Skin

The study investigated the expression of Artemis phosphorylation at serine 516 in normal human scalp skin, focusing on its role in epidermal appendages. Immunofluorescence analysis showed that Ser516 phosphorylation was present in various parts of the anagen hair follicle, sebaceous glands, eccrine sweat glands, and the epidermis, with the most prominent expression in outer root sheath keratinocytes. The findings suggested that Artemis phosphorylation at Ser516 might play a role in regulating human epidermal appendages, which could be relevant to conditions like Omenn syndrome, associated with alopecia and severe combined immunodeficiency.