Expression and Localization of Artemis Serine 516 Phosphorylation in Human Scalp Skin

The study examined the expression and localization of Artemis phosphorylation at serine 516 in human scalp skin, with a focus on its role in hair growth and skin appendage physiology. Using immunofluorescence analysis on scalp specimens from 10 healthy volunteers, researchers found that Ser516-phosphorylated Artemis was prominently expressed in the outer root sheath keratinocytes of anagen hair follicles, as well as in sebaceous and eccrine sweat glands. The phosphorylation was mainly cytoplasmic and stronger in the outer root sheath than in other skin compartments, suggesting a potential regulatory role in hair follicle biology and skin appendage function. The study emphasized the need for further research to understand the precise role of Artemis in these processes.