Antipsoriatic Activity of a New Synthetic Retinoid

    September 1983 in “ Archives of dermatology ”
    D. Tsambaos
    TLDR The new synthetic retinoid RO 13-6298 effectively treated severe psoriasis at low doses with manageable side effects.
    Two patients with severe generalized psoriasis and psoriatic arthritis, unresponsive to traditional treatments including etretinate and PUVA, were successfully treated with minimal oral dosages of the new synthetic retinoid arotinoid RO 13-6298 (0.05 to 0.1 mg/day). Side effects included dryness of the lips and nasal mucosa, palmarplantar desquamation, skin thinning, itching, and transient hair loss, but no laboratory abnormalities were found. RO 13-6298 appeared to be a highly potent antipsoriatic agent effective at very low doses.
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