Antidiabetic and Wound Healing Effects of Smeathxanthone A

The study investigated the effects of smeathxanthone A, isolated from Garcinia smeathmanii, on wound healing in diabetic mice. Twenty male albino alloxan-induced diabetic mice were divided into five groups, including normal and diabetic controls, and treated with glibenclamide or smeathxanthone A. Results showed that smeathxanthone A, particularly at 0.1 mg/kg, significantly increased skin tensile strength by 24%, stimulated hair growth, reduced inflammation, and lowered blood glucose levels by 45% compared to the diabetic control group. The study concluded that smeathxanthone A expedited wound healing by enhancing collagen deposition and controlling blood glucose, suggesting potential benefits for tissue healing.