Mechanism of Anti-Inflammatory Drugs in Early Treatment of Oral Gingival Mucosa and Soft Tissue Trauma

    January 2022 in “ Contrast Media & Molecular Imaging ”
    Yanfeng Zhu, Fei Lin, Weihui Chen
    TLDR Levofloxacin and metronidazole reduce inflammation and speed up healing in gingival wounds.
    The retracted study investigated the mechanism of anti-inflammatory drugs in the early treatment of oral gingival mucosa and soft tissue trauma. It focused on two drugs, levofloxacin and metronidazole, assessing their release properties and effects on white-eared rabbits with gingival wounds. The study measured physiological characteristics, intratissue pressure, tissue partial pressure of oxygen, IL-6 content, and PGE2 content post-injury. Results indicated that these drugs significantly inhibited IL-6 and PGE2 levels, reduced local inflammation, and accelerated tissue healing, providing theoretical support for clinical treatment of gingival trauma.
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