Mechanism of Anti-Inflammatory Drugs in Early Treatment of Oral Gingival Mucosa and Soft Tissue Trauma

    January 2022 in “ Contrast Media & Molecular Imaging ”
    Yanfeng Zhu, Fei Lin, Weihui Chen
    TLDR Levofloxacin and metronidazole reduce inflammation and speed up healing in gingival wounds.
    The study, conducted on 18 male big-eared white rabbits, investigated the effects of anti-inflammatory drugs levofloxacin and metronidazole on oral gingival mucosa and soft tissue trauma. It found that these drugs effectively managed inflammation and promoted healing by reducing levels of IL-6 and PGE2 in wound tissues, leading to faster stabilization of physiological parameters and improved wound recovery. Metronidazole showed a higher dissolution rate and superior release capacity compared to levofloxacin. However, the study was retracted, which may affect the reliability of these findings.
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