Angiokeratomas Scroti Associated with Angiokeratomas of the Eyelids: Coincidence or One Entity? A Case Report and Review of the Literature

In the 2015 case report, a patient with angiokeratomas on both the scrotum and upper eyelids was described, with the aim to explore the pathogenetic relationship between these occurrences. Angiokeratomas are vascular lesions, and while they are more common on the scrotum, their presence on the eyelids is rare. The patient exhibited multiple small reddish papules but reported no discomfort and did not seek treatment. The report hypothesized that the lesions could be due to a general weakness in the vessel walls, possibly exacerbated by the lack of adipose tissue and the support of musculofibrous structures in the skin of both the scrotum and eyelids. The symmetry and multiplicity of the lesions suggested a structural cause related to the supportive tissue of the vessels. The case report referenced Fordyce's hypothesis that atrophy of the dartos muscle might cause scrotal angiokeratomas and extended this to suggest that similar disturbances in supportive structures could be responsible for the patient's condition. The study focused on a single patient and did not provide a specific number of participants.