An Investigation of Apoptosis in Androgenetic Alopecia
June 2002
in “American Journal of Dermatopathology”
TLDR Apoptosis contributes to hair loss in androgenetic alopecia.
This document is a compilation of four different studies investigating the role of apoptosis (cell death) in androgenetic alopecia (AGA). The studies analyzed scalp biopsies from male cadavers with AGA and found differences in bcl-2 expression between affected and unaffected areas of the scalp, as well as differences in bcl-2 staining indices between frontal and occipital follicles. The studies suggest that apoptosis plays a role in the development of AGA, but further research is needed to fully understand the mechanism.
View this study on journals.lww.com →
Cited in this study
research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia
Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.
research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
research Topical minoxidil in early male pattern baldness
Minoxidil promotes hair growth in male pattern baldness.
Related
research Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining
Bim and Puma proteins are found in developing mouse hair follicles and are involved in more than just cell death.
research An investigation of apoptosis in androgenetic alopecia.
Hair loss in men might be linked to programmed cell death.
research An Investigation of Apoptosis in Androgenetic Alopecia
Apoptosis contributes to hair loss in androgenetic alopecia.