Infectious Diseases 2015: The Antimicrobial Peptides Delivery Strategies Based on Nanotechnology to Treat Infectious Diseases

In 2018, Groo Anne-Claire from the University of Angers conducted a study on the use of nanotechnology for the delivery of antimicrobial peptides (AMPs) to treat infectious diseases. The study was motivated by the growing resistance to traditional antibiotics and the potential of AMPs as new therapeutics. The research used Polymyxin B, an antimicrobial peptide, and lipid nanocapsules (LNCs) as a delivery method. The study found that Polymyxin B was efficiently encapsulated in LNCs and its antimicrobial activity remained intact. The study concluded that LNCs are an excellent candidate for delivering AMPs, suggesting that nanotechnology could improve the efficiency and stability of AMPs in clinical development.