Latest Information on Alopecia

January 2004

Satoshi Itami

androgenetic alopecia alopecia areata molecular biology hair generation

TLDR New therapies for hair loss are being developed due to advances in understanding hair growth mechanisms.

The document discussed the role of hair in mammals and its evolution in humans, where it became more of an aesthetic feature. It highlighted androgenetic alopecia, affecting about one-third of men in their 40s, and alopecia areata, an autoimmune condition, as significant causes of distress. Advances in molecular biology had clarified the mechanisms behind hair generation and these types of hair loss, paving the way for new therapies.

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research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community If follicles became miniaturized and haven’t grown in 3 years, are they dead ?

in Chat 3 years ago

Hair loss and its potential treatments, such as minoxidil, finasteride, RU58841, dermarolling, and supplements. It discusses whether miniaturized follicles can be revived to grow again or must shed for new growth to appear.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 2 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Article of all potential future cures

in Treatment 25 upvotes 6 months ago

Ritlecitinib and PP405 show promise for hair regrowth. Diagnosing the cause of hair loss is crucial before treatment.

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research Study of Skin Expression of MicroRNA-146a in Patients with Alopecia Areata

July 2018 in “Benha Journal of Applied Sciences”

Higher levels of miR-203 may contribute to hair loss in alopecia areata.