Treatment of Alopecia Areata in the DEBR Model Using Cyclosporin A Lipid Vesicles

December 2004 in “ PubMed ”

D.D Verma, S. Verma, K. J. McElwee, P Freyschmidt-Paul, Hoffman R, A Fahr

Cyclosporin A liposomal formulation alopecia areata Dundee Experimental Bald Rat model penetration enhancer ethanol hair follicle morphology CyA DEBR model PE

TLDR Cyclosporin A vesicles effectively regrow hair and reduce inflammation in alopecia areata.

This study investigated the effectiveness of 0.5% Cyclosporin A (CyA) in a liposomal formulation for treating alopecia areata (AA) using the Dundee Experimental Bald Rat (DEBR) model. Fifteen rats were divided into three groups, receiving CyA vesicles with penetration enhancer (PE), without PE, and CyA in ethanol. Groups I and II, which received CyA vesicles, showed visible hair regrowth within one to two weeks, with maximum density achieved after six weeks, along with reduced inflammation and improved hair follicle morphology. Group III, treated with CyA in ethanol, showed no hair regrowth or inflammation reduction. The study suggested that CyA vesicle formulations could be a promising topical treatment for AA in humans.

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research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

128 citations , July 2009 in “International Journal of Pharmaceutics”

PEVs improve minoxidil skin penetration, increasing hair growth.