Alopecia Areata-Like Presentations With Mogamulizumab Therapy

September 2023 in “ JAAD case reports ”

Colin M. Kincaid, Ajay Sharma, Bonnie Lee, Lauren Pinter‐Brown, Janellen Smith, Kenneth G. Linden, Natasha Atanaskova Mesinkovska

alopecia areata mogamulizumab mycosis fungoides Sézary syndrome CD8+ T-cells follicular dermatitis drug-induced alopecia

TLDR Mogamulizumab, a skin cancer drug, may cause hair loss similar to alopecia areata.

Mogamulizumab, used for treating mycosis fungoides and Sézary syndrome, has been linked to alopecia areata-like presentations. A 71-year-old man with Sézary syndrome developed widespread alopecia and follicular dermatitis after treatment with mogamulizumab. Histopathology showed a predominance of CD8+ T-cells, indicating drug-induced alopecia. After discontinuing mogamulizumab, the patient's Sézary syndrome remained in remission, and his rash resolved. This suggests that mogamulizumab-associated alopecia may be a positive prognostic factor, though further studies are needed.

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Research cited in this study

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research Alopecia Areata After Mogamulizumab Treatment

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