Alopecia Areata-Like Presentations With Mogamulizumab Therapy

September 2023 in “ JAAD case reports ”

Colin M. Kincaid, Ajay Sharma, Bonnie Lee, Lauren Pinter‐Brown, Janellen Smith, Kenneth G. Linden, Natasha Atanaskova Mesinkovska

alopecia areata mogamulizumab mycosis fungoides Sézary syndrome CD8+ T-cells follicular dermatitis drug-induced alopecia

TLDR Mogamulizumab, a skin cancer drug, may cause hair loss similar to alopecia areata.

Mogamulizumab, used for treating mycosis fungoides and Sézary syndrome, has been linked to alopecia areata-like presentations. A 71-year-old man with Sézary syndrome developed widespread alopecia and follicular dermatitis after treatment with mogamulizumab. Histopathology showed a predominance of CD8+ T-cells, indicating drug-induced alopecia. After discontinuing mogamulizumab, the patient's Sézary syndrome remained in remission, and his rash resolved. This suggests that mogamulizumab-associated alopecia may be a positive prognostic factor, though further studies are needed.

View this study on jaadcasereports.org →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Alopecia Areata After Mogamulizumab Treatment

7 citations , November 2021 in “JAAD Case Reports”

Mogamulizumab can cause hair loss and skin rashes.

research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata

60 citations , September 2015 in “Expert Review of Clinical Immunology”

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Related Community Posts Join

6 / 1000+ results

community Well here I am 3-4 years later.

in Update 56 upvotes 2 years ago

The conversation is about someone who has been taking finasteride for hair loss without success, considering switching to dutasteride or giving up treatment. Suggestions include trying dutasteride, microneedling, infrared therapy, multivitamins, and high-concentration topical solutions combining finasteride and dutasteride.

community Topical Finasteride reduced my DHT more than Oral Dutasteride

in Finasteride/Dutasteride 42 upvotes 3 years ago

Treatments for hair loss, including the experiences of topical finasteride and oral dutasteride. It also discusses Pyrilutamide, 0.025% topical concentration, Minoxidil, RU58841, and 1% finasteride gel dosage.

community I 24F have gone from a full head of hair to ~30% of hair in 2 weeks

in Female 49 upvotes 3 years ago

A 24 year old female experiencing rapid, unexplained hair loss over the course of two weeks and looking for advice. Treatments suggested include Rogaine, finasteride, minoxidil, RU58841, and seeing a dermatologist.

community Please stop looking for a natural way to stop your hairloss

in Chat 247 upvotes 4 years ago

There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

community I’m 14 years old and I’m losing more hair than my dad. I’ve gone to the doctor 2 times because of this and I’ve received no help. I’m starting to feel like It’s worthless and my hairs gonna look like this forever. I don’t know how anyone could help me but it’s always worth a shot.

in Treatment 5 years ago

A 14 year old who is experiencing hair loss and has not received any help from the doctor, with advice being given to try different doctors, get tested for underlying conditions and intolerances, buzz it short as an option and treatments that could slow down or reverse the hair loss such as minoxidil, finasteride, RU58841 and addressing the cause of the hair loss.

community Can I punch someone if they make fun of my hair loss, just like Will Smith did?

in Chat 448 upvotes 3 years ago

Hair loss's social impact, focusing on Will Smith defending Jada Pinkett Smith's alopecia. The conversation highlights double standards between men and women experiencing hair loss and emphasizes empathy.

Related Research

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.