Alopecia Areata After Mogamulizumab Treatment

November 2021 in “ JAAD Case Reports ”

Neel S. Raval, Nora A. Alexander, Karlee De Monnin, Christine C. Yokoyama, Neha Mehta‐Shah, Ilana S. Rosman, Amy Musiek

alopecia areata mogamulizumab CCR4 monoclonal antibody mycosis fungoides Sézary syndrome cutaneous granulomatous drug eruption

TLDR Mogamulizumab can cause hair loss and skin rashes.

A 42-year-old woman with Sézary syndrome developed alopecia areata universalis after 16 months of mogamulizumab treatment, which initially led to disease remission. She experienced total body hair loss but achieved full regrowth after 13 months of treatment with intralesional triamcinolone and topical clobetasol. This case suggests that mogamulizumab-induced AA may result from the depletion of regulatory T cells, disrupting immune homeostasis and leading to autoimmunity. Further studies are needed to understand the mechanistic basis and prognostic significance of mogamulizumab-associated AA.

View this study on secure.jbs.elsevierhealth.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Nivolumab-Induced Alopecia Areata: A Case Report and Literature Review

10 citations, January 2021 in “Annals of dermatology/Annals of Dermatology”

Nivolumab can cause hair loss as a rare side effect.

Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

30 citations, July 2019 in “PloS one”

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

Related Community Posts Join

6 / 1000+ results

community Alopecia Areata Question

in Treatment 2 upvotes 3 years ago

A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

community mbp alopecia areata or vitamin deficiency

in Chat 5 months ago

A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

community Olumiant alternative for Alopecia Areata?

in Treatment 1 upvotes 1 year ago

A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

community Covid (likely) induced alopecia areata - now 2nd round of Covid, what can I expect?

in Treatment 1 upvotes 1 year ago

After experiencing hair loss due to alopecia areata following COVID-19 vaccination and infection, the individual saw improvement with steroid treatments and Olumiant. They paused Olumiant during a second COVID-19 infection and expressed concern about potential hair loss flare-ups.

community Onion Juice - An effective topical treatment for Alopecia Areata 🧬

in Treatment 1 year ago

Onion juice, when applied topically, is an effective treatment for Alopecia Areata, showing significant hair regrowth in both males and females. The study suggests it could be interesting to test its effectiveness on Androgenic Alopecia.

community Nearly 40% of Adults with Alopecia Areata Taking OLUMIANT® 4-mg Saw at Least 80% Scalp Hair Coverage at 52 Weeks

in Research/Science 6 upvotes 2 years ago

Nearly 40% of adults with alopecia areata achieved at least 80% scalp hair coverage after 52 weeks of taking OLUMIANT® 4-mg. The conversation distinguishes this success from androgenetic alopecia, which is a different type of hair loss.

Related Research

1 / 1 results

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.