Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides

The study investigated age-related changes in hair shaft protein profiling and genetically variant peptides (GVPs) to understand their implications for forensic science. It analyzed hair samples from 9 individuals across different age groups and ethnicities, revealing no significant age-related differences in protein profiles within ethnic groups but noted differences between European American and African American hair. Longitudinal analysis showed modest proteomic changes over short periods but significant differences over longer intervals, with storage affecting protein degradation. Despite these changes, GVP profiles remained consistent, indicating their reliability for personal identification. The study concluded that GVPs are robust for forensic applications, providing high random match probabilities, and emphasized the need for further validation across larger populations.