Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth
TLDR Activating TRPV3 stops human hair growth.
The study concluded that activation of the Transient Receptor Potential Vanilloid-3 (TRPV3) ion channel inhibited human hair growth by suppressing cell proliferation and inducing apoptosis in outer root sheath (ORS) keratinocytes. Using human hair follicles (n=18-24 per group) and various assays, the researchers demonstrated that TRPV3 activators like eugenol and 2-APB increased calcium influx, leading to these effects. The findings suggested that TRPV3 could be a promising target for developing treatments for hair growth disorders, with potential applications for both unwanted hair growth and hair loss conditions like alopecia.
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