Actinic Hyperkeratosis Treated With Retinol Combined With a Polylysine Biovector: A Case Report
September 2025
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Studysummary In this case study, the researchers observed that a dermocosmetic formulation with encapsulated retinol led to complete regression of a chronic actinic keratosis lesion on the scalp, suggesting it may be a promising treatment approach.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report presents a 64-year-old male patient with actinic hyperkeratosis on the scalp, treated with a novel dermocosmetic formulation combining retinol and a polylysine biovector. The treatment, applied twice daily, resulted in the complete disappearance of the hyperkeratotic plaque and limited hair regrowth after 21 days, with no reported irritation or adverse effects. This suggests that the formulation could be a promising alternative to conventional treatments for actinic keratosis, which often have limitations and high recurrence rates. However, the findings are based on a single case, and larger studies are needed to confirm these results.
