Treatment of Actinic Cheilitis with Ingenol Mebutate Gel: Experience in Four Patients

    May 2015 in “ Journal of The American Academy of Dermatology ”
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    TLDR Finasteride for hair loss in young men increases the risk of sexual dysfunction.
    The document reports on a study that evaluated the risk of sexual dysfunction in young men prescribed finasteride for androgenic alopecia (AA). The study analyzed data from an electronic medical record database of 157,998 healthy men under 42 years old with no prior sexual dysfunction, who were either exposed to finasteride at a daily oral dose ≤1.25 mg or not exposed to finasteride or any other 5-alpha reductase inhibitors. The results showed that men exposed to finasteride had a significantly increased risk of impotence (hazard ratio [HR] = 3.06, number needed to harm [NNH] = 129, P<.00017), increased use of phosphodiesterase-5 inhibitors (HR= 4.8, NNH = 70.2, P<.000001), and increased risk of diminished libido (HR= 4.9, NNH = 201, P <.0001) compared to men not exposed to the drug. The study concluded that there is a highly statistically significant risk of impotence, increased PDE5I use, and diminished libido in healthy men under 42 who were prescribed finasteride for AA, suggesting a need for increased awareness in the dermatology community regarding these risks. No commercial support was identified for the study.
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      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 1 year ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 8 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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