A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia

    August 1994 in “Clinical Endocrinology
    J. B. O'Driscoll, Hari Mamtora, John Higginson, A. M. T. Pollock, John M. Kane, Dana Z. Anderson
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    TLDR Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.
    In 1994, a study involving 350 women with hirsutism and/or androgenic alopecia assessed the prevalence of polycystic ovaries (PCO) and clear-cut endocrine disorders. The study revealed that 8 women had significant endocrine disorders, while PCO was found in 81% of women with erratic menstrual cycles and 52% with regular cycles. The study highlighted the utility of high-resolution ultrasound for PCO detection and the association of PCO with insulin resistance and increased coronary artery disease risk. It recommended that a single serum testosterone measurement be included in routine assessments for such patients, and if levels exceed 5 nmol/l, a comprehensive endocrine evaluation should be conducted. This evaluation should include repeated hormone measurements and relevant tests, particularly if there is a history of amenorrhea.
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