A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice
November 1997
in “British Journal of Dermatology”
TLDR RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.
In 1997, a study involving 20 scalp grafts from balding men was conducted to investigate the effects of RU58841, a non-steroidal antiandrogen, on human hair growth. These grafts were maintained on testosterone-conditioned nude mice for 8 months and treated with either RU58841 or a control solution. The study found that grafts treated with RU58841 had a significantly higher linear hair growth rate and a higher percentage of follicles initiating a second hair cycle compared to the control grafts. However, RU58841 did not affect hair diameter. These results suggested that RU58841 could potentially be a new treatment for androgen-dependent alopecia.
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Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
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research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice
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