Non-Invasive Skin Measurement Methods and Diagnostics for Vitiligo: A Systematic Review

This study found that combining dermoscopy with reflectance confocal microscopy is more sensitive and specific than using either method alone for assessing vitiligo disease activity and treatment response. Additionally, specific characteristics observed via these techniques correlated with either good or poor treatment outcomes.

Reflectance confocal microscopy is a useful, non-invasive tool for diagnosing some skin diseases, with potential for future improvements.

This study found that both reflectance confocal microscopy and optical coherence tomography can visualize detailed hair follicle abnormalities in various skin disorders, but larger, higher-quality studies are needed for clinical implementation.

This review outlines the practical use of reflectance confocal microscopy in dermatology, detailing its applications and considerations for diagnosing various skin conditions, but reports no new findings.

This pilot study employed in-vivo multiphoton microscopy to visualize pigment-producing melanocytes in vitiligo patients, aiming to enhance understanding of treatment impacts and potentially improve transplantation therapies.