Visual Field Defect in a Patient Given Sodium Valproate Then Carbamazepine: Possible Effect of Aminotransferase Inhibition
April 2002
in “
PubMed
”
New to Valproic acid? There is a guide in the encyclopedia. Read the guide → Studysummary This case report documents a young woman who experienced a visual field defect similar to those linked to vigabatrin use, despite treatment only with valproic acid and carbamazepine, suggestive of a possible metabolic vulnerability in certain patients with specific genetic backgrounds.
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A 25-year-old woman treated with valproic acid and then carbamazepine for epilepsy developed a visual field defect similar to those seen with vigabatrin, despite not using vigabatrin. The case also involved trichorrhexis nodosa, a hair condition linked to metabolic disturbances in the urea cycle, suggesting that aminotransferase inhibition might cause various side effects, including visual abnormalities and alopecia, particularly in genetically predisposed individuals.
