Dermatologic Implications of GLP-1 Receptor Agonist Medications: A Comprehensive Review
February 2025
in “
Skin Appendage Disorders
”
TLDR GLP-1 receptor agonists can cause skin reactions, facial fat loss, and hair loss, but may help with wound healing and skin conditions.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), used for managing type 2 diabetes and obesity, have notable dermatologic effects, including injection-site reactions, hypersensitivity, urticaria, and bullous pemphigoid. "Ozempic Face," characterized by facial fat loss, and hair loss in the form of telogen effluvium, are linked to rapid weight loss from GLP-1RA use. These medications also show potential in enhancing wound healing and treating inflammatory skin conditions like psoriasis. As GLP-1RAs become more common for weight management, clinicians should monitor for dermatologic side effects and consider dermatologic consultations. Further research is needed to balance therapeutic benefits with minimizing adverse skin outcomes.
