SARS-CoV-2 Infection Reduces the Number of Spermatogonial Stem Cells and Dysregulates the Transcriptional Landscape of the Human Testis

    April 2026 in “ Research Square ”
    Miguel Brieno-Enriquez, Maria López-Panadés, Ana Martínez-Marchal, Esther Choi, Andrew Levy, Tianjiao Chu, Shruthi Shivkumar, Justin Bochter, Juan Morales, Patrick Walsh, Marta Martín‐Ruíz, Gretchen Rosado, Jimmaline Hardy, Yang Hu, J H. -C. Wang, Cristina Madrid-Sandín, Andros Maldonado-Linares, Lidia Yang, Èlia Ramos-Ramells, Lisa Barton, Eric Duval, Edana Stroberg, SANJAY MUKHOPADHYAY, Uma Chandran, Amanda Colvin Zielen, Kyle Orwig, O Elemento, Carmen Márquez, Subha Ghosh, Lluis Bassas, Guilherme Costa, Ignasi Roig
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    Studysummary This study found that COVID-19 infection disrupts spermatogenesis, alters testicular cell populations, and may impact male fertility by causing long-term changes in testicular function and reduced sperm quality, as observed even in patients who have recovered from the acute phase of the infection.
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