Baricitinib-Loaded Separable Microneedle Array Patch Based on Hyaluronic Acid for Alopecia Areata Therapy

    January 2025
    Da In Jeong, Song Yi Lee, Sungyun Kim, Seong Jin Jo, Haifeng Yang, Jae-hyuk You, ChaeRim Hwang, Ji Won Huh, Yeoung Eun Choi, W. S. Jo, In-Jeong Choi, Shunro Matsumoto, Seungki Baek, Woonsung Na, Jung‐Hwan Park, Hyun‐Jong Cho
    From the encyclopedia
    Baricitinib →

    JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

    Alopecia Areata →

    autoimmune disorder causing patchy hair loss

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    Studysummary In this study on mice, a baricitinib-loaded microneedle patch enhanced hair growth in alopecia areata lesions (68% vs control: 33%, p < 0.05), suggesting it may deliver treatment effectively and pain-free, with fewer systemic side effects.
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